Day 1 :
Queen`s University, Canada
Time : 09:00-09:30
Dr. Adrian Baranchuk, a native of Buenos Aires, Argentina, obtained his MD from the University of Buenos Aires in 1990. After qualifying in Internal Medicine and Cardiology at Sanatorio Mitre, Buenos Aires (1995), he completed a Clinical Fellowship in Cardiac Electrophysiology at the same institution under the supervision of Dr. Claudio Muratore.
He completed his Clinical Fellowship (1997) and joined the Arrhythmia Service until 2002 when he immigrated to Spain to join the Arrhythmia Service at the Fundacion Jimenez Diaz; working as a Research Fellow in the Animal Lab under the supervision of Dr. Jeronimo Farre. For his work in this lab, he was awarded with the 3rd Chinchona Award (Sponsored by 3M Foundation). During his stay in Madrid, Spain, he received a grant (as PI) from MAPFRE MEDICINA Foundation (Madrid, Spain). (Ultrasonic Analysis of Radiofrequency Lesion of the Pulmonary Venous Wall through Three-dimensional Intravascular Echography: Therapeutical Implications for Atrial Fibrillation Ablation).
Dr. Baranchuk was appointed as a Clinical Fellow in Electrophysiology at McMasterUniversity in September 2003, under the supervision of Drs. Carlos Morillo and Stuart Connolly. In 2004, he won the 1st Prize at the Fellows Forum, “5th Annual EP Fellows Course” (Sponsored by Medtronic) held in Montebello.
Dr. Baranchuk was appointed as an Assistant Professor of Medicine at Queen’s University to join the Division of Cardiology in June 2006. He is an active member of the Arrhythmia Service and has founded the EP Training Program in 2007. Currently the program has 3 Clinical Fellows.
In 2009 he received his cross-appointment with the Department of Physiology and Biomolecular Sciences.
His scholarly activity work includes sleep apnea and cardiovascular disease, specifically the link between sleep apnea and cardiac arrhythmias, complex ablation, cardiac devices and Electrophysiology and Electrocardiology education. He is a member of numerous editorial boards and reviewer of several journals. The recipient of a teaching award (Outstanding Contribution in the Core Internal Medicine Program) and nominated in 2009, 2010 & 2012 for teaching awards from the Faculty of Health Sciences. He is a member of the Mentorship Program at Queen’s University.
Dr. Baranchuk has been very active presenting his work at national and international meetings. In the last 4 years, he visited Argentina, Chile, Colombia, Venezuela, Russia, Brazil, Poland, Germany, Spain, USA; and several places in Canada.
His first book, Atlas of Advanced ECG Interpretation, has been recently released (REMEDICA, UK) and represents a big collaboration effort from well-recognized electrophysiologists of all around the world.
He has published more than 200 articles in well-recognized international journals, 20 book chapters and presented more than 150 abstracts all around the world.
He was promoted to the rank of Associate Professor of Medicine and Physiology in 2010.
Will be updated shortly
Singing River Hospital System, USA
Keynote: Tocilizumab in the treatment of acute myocardial infarction—A review of what we know with a look to the future
Time : 09:30-10:00
Matthew B. Carroll is a board certified Rheumatologist who is clinically active and currently employed by the Singing River Health System. He has had a passion for clinical research and has been an active member of the growing research team at his community hospital. He retired from the United States Air Force in 2017 but during his active duty service developed over 15 protocols and has published over 20 articles. A recent passion has been exploring the possible beneficial role of IL-6 blockade on acute myocardial infarction. He launched an ambitious protocol studying the short term effects on major adverse cardiac events which though it was eventually ended after futility analysis suggested no benefit, did enroll over 20 subjects and provided 180 day follow-up of data collection. He continues to actively lobby the study of IL-6 blockade in other areas of Cardiology.
Statement of the Problem: Tocilizumab (TCZ) is an important biologic response modifier that Rheumatologists routinely employ in the treatment of several systemic autoimmune diseases. TCZ binds to interleukin (IL)-6 receptors, inhibits cellular activation, and mitigates inflammation by IL-6. In mid-2017 TCZ was approved by the U.S. Food and Drug Administration for its first non-rheumatologic condition, the treatment of chimeric antigen receptor (CAR) T cell-induced severe or life-threatening cytokine release syndrome in patients 2 years of age or older. With this approval and with the increasing use of TCZ off-label for other nonrheumatologic conditions such as Castleman’s Disease and its variant TAFRO syndrome, where else might TCZ be successfully utilized as treatment? Recently interesting data has been published regarding possible use of TCZ in the treatment of myocardial infarction. This review will focus on the role of IL-6 and it’s receptor in myocardial inflammation and association with adverse clinical outcomes. Discussed are results from one animal study and two human trials have been published that studied the effect of TCZ in patients with acute myocardial infarction. Finally, this review summarizes the current data and makes recommendations for future clinical trial development in what hopefully will be a promising application of TCZ for a serious non-rheumatologic condition.
Florida International University, USA
Keynote: Does simulation-based training increase athletic training students’ clinical confidence and competence of performing a cardiovascular screening?
Time : 10:00-10:30
Jennifer Doherty-Restrepo is a Clinical Associate Professor and Chair of the Department of Athletic Training in the Nicole Wertheim College of Nursing and Health Sciences at Florida International University. Her areas of expertise include andragogy, simulation-based instruction, and professional as well as continuing education in athletic training. Jennifer serves the Athletic Training Profession as a manuscript reviewer for the Journal of Athletic Training and the Athletic Training Education Journal. She is an Associate Editor for the Athletic Training Education Journal. Jennifer serves the Commission on Accreditation of Athletic Training Education as a site visitor. Additionally, she is the Chair of the University and College Athletic Training Student Committee of the Athletic Trainers’ Association of Florida. In recognition of her service and contributions to athletic training education, Jennifer was the recipient of the 2015 Athletic Trainers’ Association of Florida University and College Athletic Trainer of the Year award.
Context: The need for increased screening to detect cardiac diseases in preparticipation physical examinations is a focus in athletic training. Objective: To examine if a simulation-based training can increase athletic training students’ self-reported confidence and clinical competence in conducting a cardiovascular screening. Design: Pretest-posttest design. Participants: 25 first-year athletic training students. Intervention(s): Standardized cardiovascular curriculum. Main Outcome Measure(s): Learner self-reported confidence scale, multiple-choice knowledge exam, and objective structured clinical examination (OSCE) of cardiovascular assessment skills and auditory recognition of heart murmurs. Results: Self-reported confidence increased significantly from 4.4±2.1 to 9.2±3.0 post-intervention (F = 78.7, p < 0.001) with a moderately high effect size (h2=0.789). Knowledge exam scores increased significantly from 11.0±2.5 to 13.6±4.0 post-intervention (F= 5.3, p= 0.031) with a low effect size (h2=0.191). The history-taking assessment of the OSCE increased significantly from 2.6±1.6 to 5.7±1.7 post-intervention (F= 70.1, p< 0.001) with a moderately high effect size (h2=0.751). The clinical skills assessment of the OSCE increased significantly from 4.1±2.8 to 15.6±1.6 post-intervention (F= 415.4, p< 0.001) with a high effect size (h2=0.952). Conclusions: Simulation-based training is an effective tool for increasing students’ self-reported confidence and competence in conducting a cardiovascular screening.
Loyola University Chicago, USA
Time : 10:30-11:00
Dr. Denis Larrivee is a Visiting Scholar at Loyola University Chicago and has held professorships at the Weill Cornell University Medical College in New York City and Purdue University, West Lafayette, Indiana. A former fellow at Yale University's Medical School and Department of Biology he received the Association for Research in Vision and Opthalmology's first place award for studies on photoreceptor degenerative and developmental mechanisms. He is the current editor of a text entitled Brain Computer Interfacing and Brain Dynamics with InTech Publishing and an editorial board member of the journals Annals of Neurology and Neurological Sciences (USA) and EC Neurology (UK). An International Neuroethics Society Expert he is the author of more than 50 papers and book chapters in such varied journals/venues as Neurology and Neurological Sciences (USA), EC Neurology (UK), Journal of Neuroscience, Journal of Religion and Mental Health, and IEEE Explore.
Contemplative meditation reveals a latent capacity for personal integration that enhances mental and physical heath through relational and transcendent ordering. Studies of a related meditative practice, mindfulness, reveal, for example, not only positive phenomenological benefits but also substantive physical changes in underlying neural and bodily factors, which are correlated with the duration and frequency of meditative practice. The extended intentional focus of contemplative meditation acquired from the Christian legacy, and then evolved in its later development, implicates an even greater breadth of neural deployment that assists personal integration. They suggest, thereby, a scope of disciplinary consolidation that exceeds that of mindfulness and so likely activates a broader and corresponding range of integrative processes that are latent for implementation as needed. The role played by the brain and nervous system in the self integration of higher faculties, however, is neglected in current philosophy of science models that guide empirical neuroscientific praxis; these latter, rather, are premised on the brain's mediation of coherent and coordinative operation instead of the systemically mediated, mutually constraining influences of peripheral and central neural networks. Indeed, results from contemplative meditation suggest that body and brain are unified through their ordering to higher systemic and ontological ends. Bodily performance in and through intentional actions, for example, shapes the brain and body's neural architecture to yield an integral performance unit. In like manner, higher faculties, like personal identity and intention, emerge from the extended peripheral network throughout the body to unify the whole individual in actions, such as those promoted in contemplative meditation. This paper will pursue an evidence based presentation, discussing the underlying neural events through which self autonomous actions promote and assist personal integration.
Tufts University School of Medicine, USA
Time : 11:00-11:30
Amir Lotfi is an associate professor of medicine, Tufts University School of medicine in the cardiology division at Baystate Medical Center. His training in coronary, carotid and peripheral interventions. His area of interest includes radial intervention, coronary physiology, coronary imaging, and ischemic preconditioning.
Statement of the Problem:
Patients' intra and post procedural comfort, quick recovery, as well as procedure success, are key elements for choosing the right arterial access site. Radial artery access has been of increasing interest since it was first described. Advanced treatments of coronary lesions, from primary percutaneous interventions during ST elevation myocardial infarction cases to chronic total occlusion cases, have been increasingly done through the radial access. Distal left trans radial artery (dlTRA) is a new technique first described by Kiemineij. We report the first documented US experience of the left distal radial artery access for coronary angiography and interventions.
Methodology & Theoretical Orientation:
dlTRA was attempted on 22 consecutive patients, consented for a cardiac catheterization. 7 patients underwent percutaneous coronary intervention. The left hand is prepped in the usual fashion, exposing the anatomical snuff box. Under ultrasound guidance, the artery is punctured and the sheath is inserted carefully. The cardiac catheterization is completed using standard diagnostic and guiding catheters that are typically chosen for femoral artery access. Haemostasis was achieved with a radial band. Patients had the ability to use the right hand as well as bend their left wrist post procedure.
Conclusion & Significance:
dlTRA was successful in all 22 patients. 7 patients underwent PCI through this approach. Two patients required a multi vessel complex PCI with multiple stents and additional equipment. There were no conversions to the right radial or femoral approach. All patients had excellent haemostasis with a radial band, with no complications. Pre discharge radial pulses were intact in the wrist as well as in the anatomical snuff box. Distal left trans radial access is feasible and safe in patients that are carefully selected and are deemed good candidates. There is a learning curve for developing such program, as is the case with conventional radial access.
- Sessions: Anaesthesiology | Autopsy | Cancer Science | Cardiology | Clinical Pathology | Dentistry | Dermatology and Skin Care | Diabetes | Critical Care and Emergency Medicine | Epidemiology | Forensic and Legal Medicine | Gastroenterology | Geriatric Medicine | Internal Medicine | Microbiology | Neurology | Obstetrics and Gynaecology | Ophthalmology | Orthopaedics & Rheumatology | Paediatrics | Pathology- Anatomy & Clinical | Pharmacology and Therapeutics | Psychology | Public Health | Pulmonology | Radiology | Sexual Health | Surgery | Toxicology | Urology | Vascular and Endovascular Surgery | Veterinary | Women’s Health | Miscellaneous Case Reports
McMaster University, Canada
Dr. Ronish Gupta is a pediatric intensivist at the McMaster Children’s Hospital and an Assistant Professor with McMaster University. He completed medical training at Queen’s University in Kingston, Canada. This was followed by residency and fellowship training at the University of Ottawa, Canada. His academic interests revolve around medical education, and include critical care simulation, interprofessional curriculum development, and resident selection. He also regularly utilizes noteworthy case reports as a means of scholarship and teaching.
A 2-year-old generally healthy boy with a history of limping gait presented and was admitted to a community hospital with severe Influenza A illness. There, he was intubated for refractory hypoxia, and found to have large bilateral pleural effusions. Bilateral chest tubes were inserted, draining > 1 L of milky fluid combined. He was transferred to the regional pediatric intensive care unit. With the effusions drained, he was easily extubated and biochemical testing confirmed the fluid to be chyle (triglyceride level = 3.48 mmol/L). Computed tomography scanning of the chest and abdomen was subsequently negative for malignancy, but incidentally found rib fractures, scapular fracture, and an unstable spinal subluxation (T11-L1). In the interim and during spinal surgical planning, the high-output chylothorax continued despite several days of NPO status with total parenteral nutrition (> 1L/d or > 50mL/kg/d). Following reduction and partial fixation of the spinal subluxation, the pleural drainage immediately ceased. Within 24-hours following surgery, the drainage became < 50mL/d. Two weeks later, the chylous drainage remained absent with the patient on a full enteral medium-chain triglyceride containing diet.
Acquired chylothorax in pediatrics is typically associated with mediastinal pathology (e.g. trauma, infiltrative), obstruction of drainage, or abnormal lymphatic vessel development. Case reports of chylothorax developing following spinal trauma and manipulation exist. This is, however, the first report to our knowledge of chylothorax resolution as a result of spinal intervention. Potential mechanisms include relief of obstruction of the cysterna chylii, the large lymphatic reservoir typically located adjacent to the L1-L2 vertebral bodies. Patients with chylothorax in the context of thoracolumbar spinal pathology may warrant consideration of an intervention aimed at relieving any potential lymphatic obstruction.
1. Pillay TG, Singh B. A review of traumatic chylothorax. Injury. 2016;47(3):545-550. doi:10.1016/j.injury.2015.12.015.
2. Bender B, Murthy V, Chamberlain RS. The changing management of chylothorax in the modern era. Eur J Cardio-thoracic Surg. 2016;49(1):18-24. doi:10.1093/ejcts/ezv041.
3. Ichikawa Y, Sato A, Sato K, et al. Chylothorax associated with child abuse. Pediatr Int. 2015;57(6):1202-1204. doi:10.1111/ped.12707.
4. Mora de Sambricio A, Garrido Stratenwerth E. Chylothorax following anterior thoraco-lumbar spine exposure. A case report and review of literature. Rev Española Cirugía Ortopédica y Traumatol (English Ed. 2015;59(2):129-133. doi:10.1016/j.recote.2015.01.002.
5. Gartside R, Hebert JC. Chylothorax following fracture of the thoracolumbar spine. Injury. 1988;19(5):363-364.
Military Hospital Berlin, Germany
Wilk is a resident at the Military Hospital of the German Armed Forces Department of Anesthesiology Intensive Care and Emergency Medicine in BERLIN, GERMANY, where her functions includes research coordination and education. She holds PhD in prehospital emergency communication and MD degree from the University of JENA, GERMANY. She is author of research paper in the German magazine of Anesthesiology and coauthor in World Journal of Emergency Medicine and was speaker at several medical congresses. She is a member of the State Chamber of Physicians of Berlin and Brandenburg and former president of Deutscher SanOA e.V. and presidium member of the Germany Society of Military Medicine and Pharmacy DGWMP (2014-2016). She developed special skills in management during her time as presidium member of the German Red Cross / KV Fläming Spreewald (2008-2010). Wilk has special interest in tactical military medicine and is member of the TREMA Tactical Rescue & Emergency Medicine Association.
Communication failure in prehospital emergency medicine can affect patient safety. We analyzed the database of the critical incident reporting system (CIRS) for prehospital emergency medicine in Germany retrospectively regarding communication errors. There it was demonstrated that in 30% of cases deficient communication led to a threat to patients; however, the analysis did not show what exactly the most dangerous work processes are. An out-of-hospital workflow analysis collected data about key work processes and risk areas. The analysis points out confounding factors for a sufficient communication. Almost 70% of critical incidents are based on human factors. Factors, such as communication and teamwork have an impact but fatigue, noise levels and illness also have a major influence. Both analysis showed up that communication between physicians and non-physicians were the biggest risk focus for incidents as well as interface communication. For example: In one case, a paramedic injected without further communication 8 g glucose in a comatose patient, although the blood sugar was not measured yet. At the end, the patient had a cerebrovascular accident without a hypoglycaemia.
Team members do have the need to communicate about decisions in order to understand the thought process of the other. Patient transfer and the high-risk area of emergency care are vulnerable for communication failure and patient threat. In summary, communication deficits in emergency medicine have not been studied sufficiently enough. A better communication strategy and teaching communication skills will have enormous effect in increasing patient safety. Organized structured information transfer and handovers are helpful and we also need to train closed-loop-communication. Communication techniques should be part of the training of paramedics and physicians. More than that emergency medicine should focus on education and research on communication aspects.
Saeed El-Ashram is an Associate Professor at College of life science and Engineering, Foshan University, 18 jiangwan street, Foshan 528231, Guangdong province，China. He is also the Inventor of “Compositions and methods of enhancing immune responses to Eimeria” (United States Patent 8956849). Dr. Saeed El-Ashram scientific interests include Infectious diseases, Immunology, Vaccinology, Proteomics, Immunoproteomics and Next -Generation Sequencing (MiSeq and HiSeq). His recent publications include Electrical cream separator coupled with vacuum filtration for the purification of eimerian oocysts and trichostrongylid eggs (Scientific Reports), Clustering by fast search and merge of local density peaks for gene expression microarray data (Scientific Reports), Exploring the microbial community (microflora) associated with ovine Haemonchus contortus (macroflora) field strains (Scientific Reports), Co-infection of Chlamydia psittaci with H9N2, ORT and Aspergillus fumigatus contributes to severe pneumonia and high mortality in SPF chickens(Scientific Reports), Gel Mapping to Differentiate between Sporozoites of Two Immunologically Distinct Strains of Eimeria maxima (Strains M6 and Guelph ) (PLoS One), Interferon-Gamma Release Assay,Exploring Early and Late Toxoplasma gondii Strain RH Infection by Two-Dimensional Immunoblots of Chicken Immunoglobulin G and M (PLoS One), Mycoplasma gallisepticum MGA_0676 is a membrane-associated cytotoxic nuclease with a staphylococcal nuclease region essential for nuclear (Appl Microbiol Biotechnol), and Improved Cytotoxic T Lymphocyte Responses to Vaccination with Porcine Reproductive and Respiratory Syndrome Virus in 4-1BB Transgenic Pigs (Front Immunol. 2017).
The recognition and elimination of eukaryotic parasites appear to be a hardwired prerequisite for host survival. However, eukaryotic parasites such as Toxoplasma gondii, Leishmania sp., Trypanosoma cruzi, Giardia sp., and Schistosoma sp. employ the innate system of the host for their growth, replication, and continuation of their life cycle. So far, however, there has been little discussion about the interaction of the eukaryotic parasites and the innate immune system. Driven by this need, this review provides an overview of the host-oriented inherent measures and eukaryotic parasite countermeasures for evading host defenses. Additionally, this review discusses control of parasite and its evasion strategy at innate and adaptive arms of the immune system. Taken together, this information could be exploited to discover novel therapies, vaccine strategies and prophylactic intervention points for broad-spectrum host-oriented inherent measures and eukaryotic parasite counter-measures, and to understand the parasitic disease progression and the infection consequence.
Keywords: Eukaryotic parasites; Innate immune system; Therapeutic and prophylactic intervention
Sakra Hospitals, India
Prof. Dr. C.V. Harinarayan is an excellent clinician, accomplished research scientist, astute bed-side investigator, exemplary organizer and administrator. He has made pioneering contribution and played a key role in placing the specialty of endocrinology on the global map. His work is distinguished service of a high order. He has many indexed publications in reputed journals and his work is cited by many researchers (1065 cites/year). His research work is quoted in many textbooks of metabolic bone disease has provided new perspectives in the correct diagnosis and treatment of metabolic bone diseases. His documentation on the low vitamin D status as the cause of bone disease in primary hyperparathyroidism, documentation of the low vitamin D levels in urban and rural subjects through population survey, his work on dietary calcium and vitamin D status of Indian population potentially changed the Recommended Dietary Allowances (RDA) of India has paved the way for fortification of Food with vitamin D in the country especially for those who are indoors for most of the day. His work of the renal tubular damage as the cause of bone disease in fluorosis is ranked top 10 publications - year 2006 by Internet. He has indigenously developed intact IRMA radioimmunoassay for parathyroid hormone in India along with BARC Mumbai and was a co-chair for development of “Clinical Practice Guidelines on management of Postmenopausal osteoporosis (2012-13) – Executive summary and Recommendations” for Indian Menopause society. His in vitro studies on ampoule model of previtamin D synthesis has shown that we as Indians can synthesize enough vitamin D on exposure to sunlight from 11 am to 2 pm, by exposing 10 to 15% of body surface area for 15 to 30 minutes. He also showed that correction of vitamin D deficiency can improve the pancreatic beta cell secretory function.
The Commonest cause of primary hyperparathyroidism (PHPT) is hyper-functional parathyroid adenoma (PA)(94%) hyperplasia(<6%) rarely parathyroid carcinoma(<1%). Parathyroidectomy is a definitive cure with a success rate of 95 %. Less than 15% have one or more hyper-functioning glands in the ectopic location.
Materials and Methods:
Between 2014 to 2017, seven of the 13 patients with PHPT and failed non-invasive localization were included for the study. Hybrid localization techniques with PET/CT and newer tracer agents (11C-methionine) were used. Locations of parathyroid adenoma were classified using Perrier classification which uses letters A-G to describe the exact location of the adenoma. A 50 % drop in PTH levels as compared with pre-incision values was confirmed as cure.
The biochemical and hormonal profile of the 7 patients with ectopic PA are (mean+SD) serum calcium (mg/dl), 25OH-D (ng/dl) and PTH (pg/ml) 11.36+0.82;22.82+8.57; 205+105 respectively. Forty three percent (3/7) had renal stones. In all seven patients PA was localized using PET/CT scans and tracer agents 11C-choline. The profile of PA were two type-G (intra-thyroidal), one type-C (posterior mediastinum), two type-F (Superior mediastinum), one of type D(mid region of posterior surface of thyroid parenchyma at the junction of recurrent laryngeal nerve and the middle thyroidal vein).
Ectopic PA is rare. In a biochemically and hormonally confirmed PHPT and failed imaging localization techniques/failed neck exploration one should look for ectopic PA. Newer hybrid techniques combined with newer tracer agents (PET scan) will help in localization of PA. To the best of our knowledge this is the first report of series of ectopic PA from a single centre from India.